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This course introduces the fundamentals of medical instrumentation systems, and bio-signal processing. The physiology of bio-signals, including how they are generated, recorded/collected and are used clinically, will be presented. The purpose of the signal processing methods ranges from noise and artifact reduction to extraction of clinically significant features. The course gives each participant the opportunity to study the performance of a method on real bio-signals. The major topics covered in this module are: Basic concepts of biomedical engineering, cardiovascular, respiratory, neuro -physiological measurements, X-ray, ultrasound, nuclear, and MRI. How these images are formed and what types of information they provide will be presented. Testing of audio ability and hearing. Optical measurements in medical systems.